This is a game I have been looking at for quite some time, but my gaming group never seem to have time or interest in playing:
Where No Man Has Gone Before 2.0
http://trek.abillionmonkeys.com/
Here is a setting that is more or less rules agnostic. It is produced in 3 blog posts. Has some interesting ideas:
I have been thinking of combining this setting with some lite rule system, perhaps ‘Where No Man Has Gone Before 2.0’, but I would need to know there are some players looking to use it.